I’m always on the lookout for potential ways to extend my life. The science of aging is so new that things are changing rapidly, so we’ll see how it all plays out. NMN and NR (nicotinamide mononucleotide and nicotinamide riboside) are derivatives of niacin, or vitamin B3. Our bodies can synthesize them from nicotinamide, which can be derived from tryptophan or sourced directly as a vitamin supplement. They’re found in certain foods, like avocados and cabbage, but very little research has been done in humans, and the data on efficacy is mixed. Also, there’s concern about long-term effects of supplementation because the pathways that lead toward NAD+ synthesis have not been completely mapped (yet).”
I’m always on the lookout for potential ways to extend my life. The science of aging is so new that things are changing rapidly, so we’ll see how it all plays out.
I’m always on the lookout for potential ways to extend my life. The science of aging is so new that things are changing rapidly, so we’ll see how it all plays out.
NMN and NR are derivatives of niacin, or vitamin B3, which is found in certain foods like avocados and cabbage. They have not been completely mapped yet (at least as far as we know), but they’re believed to increase NAD+ levels in cells by restoring them after they’ve been depleted by age-related stressors like free radicals.
NMN and NR (nicotinamide mononucleotide and nicotinamide riboside) are derivatives of niacin, or vitamin B3. Our bodies can synthesize them from nicotinamide, which can be derived from tryptophan or sourced directly as a vitamin supplement. They’re found in certain foods, like avocados and cabbage, but very little research has been done in humans, and the data on efficacy is mixed. Also, there’s concern about long-term effects of supplementation because the pathways that lead toward NAD+ synthesis have not been completely mapped (yet).
A 2012 study determined that giving NMN to mice both increased their lifespan and increased their physical functioning. In 2017 a study was done using NR in humans, but it was difficult to determine efficacy because after 4 weeks NAD+ levels had declined again to baseline levels.
NMN and NR are derivatives of niacin, or vitamin B3. Our bodies can synthesize them from nicotinamide, which can be derived from tryptophan or sourced directly as a vitamin supplement. A 2012 study determined that giving NMN to mice both increased their lifespan and increased their physical functioning. In 2017 a study was done using NR in humans, but it was difficult to determine efficacy because after 4 weeks NAD+ levels had declined again to baseline levels
Conclusion
The results of this study suggest that NMN may be effective in increasing NAD+ levels in humans. Additional research is needed to determine whether increased NAD+ levels can lead to longer lifespans and improved health outcomes for older adults.