Scientists have reportedly made a groundbreaking discovery in reversing the signs of aging in mice. Two research groups in the US have found that by fixing the mice’s DNA, they were able to stop them from getting old. According to Dr. Marty Makary, a health policy expert at Johns Hopkins, “there is new research now showing that the aging process may be reversible.” This means that the body may carry a copy of a gene that codes for a younger response to everything physiologically.
In a recent study published in the journal Cell on January 12th, Harvard scientists were able to manipulate and reverse the aging process in mice by generating DNA repairs. The results of a 13-year, international study show that the breakdown in epigenetic information accelerates aging in mice and that repairing the epigenome can reverse those signs of aging. The study suggests that aging has a significant epigenetic component, which is the process by which stretches of DNA or the genes are turned on and off.
The senior author of the paper, David Sinclair, Professor of Genetics at the Blavatnik Institute at Harvard Medical School, and Co-Director of the Paul F. Glenn Center for Biology of Aging Research, said that “We believe ours is the first study to show epigenetic change as a primary driver of aging in mammals.” The researchers at Harvard have stated that they want to test their findings on larger mammals and, eventually, on people. “First, the results need to be replicated in larger mammals and in humans. Studies in nonhuman primates are currently underway,” Harvard said in a statement.
What does that mean for us ?
The recent discovery of reversing the signs of aging in mice by Harvard scientists is certainly exciting, but it is important to note that the results need to be replicated in larger mammals and in humans. Studies in nonhuman primates are currently underway, according to Harvard’s statement.
However, even though this discovery is promising, it will take some time before it is available for human use. As longevity expert Aubrey de Grey describes in his concept of “longevity escape velocity”, we need to make it to a point in time where the technology to extend human lifespan can be used. Whether that will be 5 years or 10 years from now is uncertain.
In the meantime, there are steps that individuals can take to improve their health and potentially promote longevity. These include practicing intermittent fasting, following a ketogenic diet, reducing blood sugar spikes, and taking short walks. These actions can be used as a way to bridge the gap between now and the time when these new discoveries are available for human use.
Aging is the process of becoming older and the gradual decline in function and physical ability that comes with it. It is a complex process that is not fully understood but is thought to be influenced by a combination of genetic, environmental, and lifestyle factors.
Eating a healthy diet is one of the most important things you can do for your overall health and longevity. This means eating a diet that is rich in whole, nutrient-dense foods like fruits, vegetables, whole grains, and lean protein. Avoiding processed foods, added sugars, and saturated fats can also be beneficial. Eating a diet that is rich in antioxidants, polyphenols, and other nutrients that have been shown to promote longevity, such as those found in fruits, vegetables, nuts, and whole grains, is a great way to support overall health.
Exercise is another important factor in promoting longevity. Regular physical activity has been shown to reduce the risk of chronic diseases like heart disease, diabetes, and cancer, and also helps to improve cardiovascular fitness, muscle mass, and bone density. Exercise is also beneficial for mental health, helping to reduce stress and improve mood.
Intermittent fasting is a pattern of eating that involves alternating periods of eating with periods of fasting. This type of eating has been shown to have a number of health benefits, including weight loss, improved insulin sensitivity, and increased longevity. Research suggests that intermittent fasting can also help to improve cardiovascular health, lower inflammation, and boost brain function.
Following a ketogenic diet, is a high-fat, moderate-protein, and low-carbohydrate diet that encourages the body to burn fat for fuel instead of carbohydrates. This type of diet has been shown to have a number of health benefits, including weight loss, improved insulin sensitivity, and increased longevity. Additionally, a ketogenic diet may also help to improve mental clarity and focus, lower inflammation, and boost brain function.
Reducing blood sugar spikes is also an important factor in promoting longevity. This can be done by eating a diet that is low in refined carbohydrates and added sugars, and by avoiding foods that are high in processed sugars and refined flour. Additionally, taking supplements such as Berberine and metformin, and engaging in activities like walking which helps to reduce blood sugar levels better than metformin.
Finally, reducing stress is another important factor in promoting longevity. Stress can take a toll on the body and mind, and has been linked to a number of health problems, including heart disease, diabetes, and depression. Taking steps to reduce stress, such as meditation, yoga, or other relaxation techniques, can help to improve overall health and longevity.
Here are some helpful supplements that can significantly slow down aging.
A 5-10 minute walk has been shown to reduce blood sugar better than metformin. Studies have shown that short walks can help to lower blood sugar levels and improve insulin sensitivity, which can be beneficial for preventing diabetes and other chronic diseases. Short walks are also an easy way to increase physical activity and improve overall health.
Nicotinamide Mononucleotide (NMN) is a molecule that is a precursor to NAD+, a vital coenzyme that plays a role in energy metabolism and DNA repair. NAD+ levels decline with age and is thought to contribute to the aging process. Studies have shown that supplementing with NMN can help to boost NAD+ levels and improve energy metabolism, which may have anti-aging effects. NMN has been shown to improve glucose metabolism, enhance endurance, and protect against oxidative stress, inflammation, and DNA damage.
Metformin is a drug commonly used to treat type 2 diabetes, but recent research suggests it may also have anti-aging properties. Studies have shown that metformin may help to reduce the risk of chronic diseases like cancer, heart disease, and stroke, and may also improve longevity. Metformin has been shown to improve glucose metabolism, enhance endurance, and protect against oxidative stress, inflammation, and DNA damage. Metformin has also been shown to have beneficial effects on weight loss, blood sugar, and blood pressure.
Current cutting-edge treatments for aging include nicotinamide mononucleotide (NMN) and metformin. NMN is a precursor to NAD+ which is a vital coenzyme that plays a role in energy metabolism and DNA repair. Metformin is a drug commonly used to treat type 2 diabetes, but recent research suggests it may also have anti-aging properties. Berberine is a compound found in plants like barberry, goldenseal, and Oregon grape, it has been used in traditional medicine to lower blood sugar levels and help with weight loss, and research has also suggested it may have potential anti-aging effects.
Another treatment that has been shown to have potential anti-aging effects is rapamycin. Rapamycin is an immunosuppressant drug used to prevent organ rejection in transplant patients, but recent research suggests it may also have anti-aging properties by inhibiting the target of rapamycin (TOR) signaling pathway.
Rapamycin is an immunosuppressant drug used to prevent organ rejection in transplant patients, but recent research suggests it may also have anti-aging properties by inhibiting the target of rapamycin (TOR) signaling pathway. Rapamycin has been shown to improve glucose metabolism, enhance endurance, and protect against oxidative stress, inflammation, and DNA damage. Rapamycin has also been shown to extend lifespan in animals and may be useful in treating age-related diseases such as cancer, Alzheimer’s, and cardiovascular disease.
Berberine is a compound found in plants like barberry, goldenseal, and Oregon grape. Berberine has been used in traditional medicine to lower blood sugar levels and help with weight loss. Research has also suggested it may have potential anti-aging effects. Berberine has been shown to improve glucose metabolism, enhance endurance, and protect against oxidative stress, inflammation, and DNA damage. Berberine has also been shown to lower cholesterol and blood pressure and reduce the risk of heart disease.
In terms of future potential, there are a number of promising avenues of research being explored. These include the use of senolytic drugs to target and eliminate senescent cells, which are cells that have stopped dividing and may contribute to aging, and the use of stem cell therapy to rejuvenate aging tissues and organs.
As for what you can do for now to promote longevity, eating a healthy diet, exercising regularly, and reducing stress are all important. Additionally, taking supplements such as NMN and liposomal, as well as
Taking supplements is another way to support overall health and longevity. Supplements such as NMN and liposomal can help to boost NAD+ levels, which are important for energy metabolism and DNA repair. Additionally, other supplements such as vitamin D, omega-3 fatty acids, and vitamin C may also be beneficial for promoting longevity.
Do you take any supplements for longevity? Please comment with your experience!
by Eric Nelson